Mechanisms of antidepressant resistance
نویسندگان
چکیده
منابع مشابه
Mechanisms of antidepressant resistance
Depression is one of the most frequent and severe mental disorder. Since the discovery of antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds, several classes of psychotropic drugs have shown be effective in treating major depressive disorder (MDD). However, there is a wide range of variability in response to ADs that might lead to non response or partia...
متن کاملMechanisms underlying the antidepressant response and treatment resistance
Depression is a complex and heterogeneous disorder affecting millions of Americans. There are several different medications and other treatments that are available and effective for many patients with depression. However, a substantial percentage of patients fail to achieve remission with these currently available interventions, and relapse rates are high. Therefore, it is necessary to determin...
متن کاملMechanisms contributing to antidepressant zinc actions.
Zinc is a trace element, which is an important modulator of mammalian nervous and immune systems. Its deficiency is related to human depression. Our recent data indicate involvement of zinc in the mechanism of antidepressant treatment. Moreover, zinc exhibits antidepressant-like effects in animal models of depression in rodents. Since zinc also enhances antidepressant effect in laboratory anima...
متن کاملAre two antidepressant mechanisms better than one?
338 J Clin Psychiatry 58:8, August 1997 © Coyright 997 Phsicians Poraduate Pess, nc. ne pesonal opy ay be pinted New drugs with multiple mechanisms may not only be able to reduce side effects, they might even improve antidepressant efficacy. There is a troubling clinical notion, especially among some investigators, that the SSRIs are not as powerful as the TCAs for treating patients who have se...
متن کاملReview Mechanisms Contributing to Antidepressant Zinc Actions
Zinc is a trace element, which is an important modulator of mammalian nervous and immune systems. Its deficiency is related to human depression. Our recent data indicate involvement of zinc in the mechanism of antidepressant treatment. Moreover, zinc exhibits antidepressant-like effects in animal models of depression in rodents. Since zinc also enhances antidepressant effect in laboratory anima...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2013
ISSN: 1663-9812
DOI: 10.3389/fphar.2013.00146